Curator’s Summary: A recent phase 2b trial on MM120, a pharmaceutical form of LSD, demonstrated that a single dose can reverse generalized anxiety disorder (GAD) in adults. Conducted with 198 participants, the optimal dose of 100 micrograms significantly reduced anxiety scores for up to 12 weeks, with nearly 50% achieving remission. MM120 uniquely targets serotonin 5-HT2A receptors, promoting brain “re-wiring” without reliance on daily medications like traditional treatments, which often lead to dependence. Most side effects were mild and reversible, indicating a favorable safety profile. With phase 3 trials underway, MM120 shows promise in transforming GAD management.
A recent study investigating a pharmaceutical form of LSD (known as MM120) has revealed that this single-dose entity has the power to reverse generalized anxiety disorder (GAD).
The phase 2b JAMA trial enrolled 198 adults with moderate-to-severe GAD across 22 psychiatric research sites in the United States, testing doses ranging from 25 to 200 micrograms in a randomized, double-blind design.
The result revealed that the optimal MM120 dose of 100 micrograms reduced Hamilton Anxiety Rating Scale scores by 5-6 points in the experimental group, and this effect was sustained for 12 weeks.
A landmark study challenging conventional GAD management
Serotonin reuptake inhibitors and benzodiazepines can selectively control anxiety, and their regular administration increases the risk of dependence. Even with these medicines, many people still struggle with anxiety that adversely impacts their health-related quality of life.
This groundbreaking study revealed that MM120 adopts a non-conventional approach by inducing serotonin 5-HT2A receptors in a way that may help the brain form novel networks for surpassing old anxiety patterns while bypassing the need for daily treatment. This re-wiring of the human brain with MM120 may truly revolutionize the landscape of GAD treatment.
The study results showed that after three months of MM120 therapy, nearly 50% of the participants had their anxiety rest in remission. Many also reported better sleep, improved mood, and a stable return to their regular routines.
Safety outcomes
Most adverse events were mild, temporary, and reversible, such as short-term visual changes, nausea, or headaches. These were resolved within a few hours with focused medical care.
Notably, there were no serious drug-related issues or addiction problems. The study ensured to exclude those with a history of psychosis or substance dependence. Participants were between 18 and 74 years old. They included a balanced mix of genders, suggesting the treatment could help a variety of people.
With the phase 3 trial underway and FDA breakthrough therapy designation already granted, MM120 could change how GAD is treated by offering a simpler therapy for faster, yet long-lasting, relief.
Carefully monitored dosing rooms, strict medical screening, and mostly mild, transient side effects suggest a favorable safety profile when MM120 is given in controlled settings, avoiding the dependence and withdrawal issues seen with benzodiazepines.
Key takeaway
MM120 may help the anxious brain “re-wire” for more positive connectivity by strengthening neuroplasticity and untangling rigid worry loops through 5-HT2A receptor activation. That day may not be too far off when MM120-type treatment proves to be the most potent blueprint for GAD management.
Watch this insightful educational podcast to learn more about MM120 mechanics and how this simple yet powerful single-dose treatment can revolutionize GAD management and instill hope in millions of people striving for authentic, impactful therapies.
Reference
Robison R, Barrow R, Conant C, Foster E, Freedman JM, Jacobsen PL, Jemison J, Karas SM, Karlin DR, Solomon TM, Halperin Wernli M, Fava M. Single Treatment With MM120 (Lysergide) in Generalized Anxiety Disorder: A Randomized Clinical Trial. JAMA. 2025 Oct 21;334(15):1358-1372. doi: 10.1001/jama.2025.13481. PMID: 40906494; PMCID: PMC12412041.
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Dr. Khalid Rahman Health Scientist | Scholarly Communicator | Licensed Integrative Medicine Practitioner PhD (Clinical Research) | MSc (Bioinformatics) | MSc (Clinical Research & Regulatory Affairs) | Post Graduate Diploma in Computer Application | Bachelor of Unani Medicine & Surgery
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